PAI 675 4G/5G

The PAI-1 4G/5G test looks at a common variation in the gene for plasminogen activator inhibitor-1 (PAI-1), a protein that slows down the breakdown of blood clots. It is usually requested as part of a wider thrombophilia (clotting) work-up.

What the test looks for

After a clot has done its job, the body breaks it down through a process called fibrinolysis. PAI-1 acts as a brake on that process. The SERPINE1 gene, which makes PAI-1, has a common variation in its promoter region at position −675, where people carry either four G bases (4G) or five (5G).

Each person has two copies of the gene, so the result is 4G/4G, 4G/5G or 5G/5G. Studies have linked the 4G version with higher PAI-1 levels in the blood. Researchers have looked at it in relation to blood clots, heart and blood vessel disease and some pregnancy complications, but its clinical value on its own is still debated.

Who might consider it

• People having a thrombophilia work-up because of blood clots, usually alongside tests such as Factor V Leiden and the prothrombin 20210 mutation
• Women being investigated for recurrent pregnancy loss, when their doctor includes it in the panel
• People whose doctor has asked for it specifically

Before you book

The test uses one blood sample. Our team can collect it at your home or office anywhere in Dubai, or you can visit our lab in Al Karama or Al Barsha 1. The lab asks for a signed consent form and your relevant medical history with the sample, as it does for all genetic tests. Results are usually ready in 5–7 days.

Understanding your results

The report gives your genotype: 4G/4G, 4G/5G or 5G/5G. This result describes a common variation, not a disease. It should not be used alone to make decisions about blood thinners or pregnancy care. Your doctor interprets it together with your history and your other clotting results.