F13A1 V34L

The F13A1 V34L test looks at a common variation in the gene for factor XIII, the protein that strengthens and stabilises a blood clot in the last step of clotting. It is usually requested as part of a wider clotting gene profile.

What the test looks for

Factor XIII links the strands of a clot together so it holds firm. The F13A1 gene makes its A subunit. A common variation at position 34 changes the amino acid valine (V) to leucine (L). The leucine version makes factor XIII activate more quickly, and researchers have studied how this affects clot structure and clotting risk. On its own, the variation does not diagnose a condition.

Each person has two copies of the gene, so the result is VV, VL or LL.

Who might consider it

• People having a broader thrombophilia or clotting gene profile at their doctor’s request
• People whose doctor wants to look at it alongside tests such as Factor V Leiden and the PAI-1 4G/5G test

This genetic test is different from a factor XIII activity test, which measures how well factor XIII is working in your blood.

Before you book

The test uses one blood sample. Our team can collect it at your home or office anywhere in Dubai, or you can visit our lab in Al Karama or Al Barsha 1. The lab asks for a signed consent form and your relevant medical history with the sample, as it does for all genetic tests. Results are usually ready in 10–14 days.

Understanding your results

The report gives your genotype: VV, VL or LL. It describes a common variation, not a disease, and should not be used alone to make decisions about treatment. Your doctor interprets it together with your history and your other clotting results.