Recurrent Abortion Genetic Profile Test – Protein C, S, Factor V Leiden & Antithrombin III Analysis

Description

Recurrent Abortion Genetic Profile Test – Protein C, S, Factor V Leiden & Antithrombin III Analysis

The Recurrent Abortion Genetic Profile Test from Lab Tests Dubai is a specialized diagnostic paneldesigned to identify inherited thrombophilias—genetic blood clotting disorders that are a leading cause of unexplained recurrent pregnancy loss.

This advanced test evaluates:

• Protein C
• Protein S
• Antithrombin III
• Factor V Leiden Mutation (F5)
• Activated Protein C Resistance (APCR)

Using functional assays, ELISA, and PCR-based DNA analysis, this test delivers highly accurate results within 7 days (in-house)—making it essential for:

• Women with two or more unexplained miscarriages (before 20 weeks)
• Those with late pregnancy loss, stillbirth, or intrauterine growth restriction (IUGR)
• Patients with preeclampsia, placental abruption, or IVF failure
• Individuals with a family history of thrombophilia or DVT

Available with confidential home blood collection, Lab Tests Dubai supports fertility specialists, OB-GYNs, and womenon their journey to a healthy pregnancy—offering answers, clarity, and hope.

Why You Need This Test

If you’ve experienced repeated miscarriages, this test could reveal the hidden cause.

You need this panel if:

• You’ve had two or more consecutive pregnancy losses
• You’ve suffered late first-trimester or early second-trimester miscarriages
• You have a family history of blood clots or thrombophilia
• You’ve had preeclampsia, placental insufficiency, or IUGR
• You’re undergoing IVF or fertility treatment with unexplained failure
• You’ve been diagnosed with antiphospholipid syndrome (APS) and need full thrombophilia workup

These conditions can impair placental blood flow, leading to:

• Poor implantation
• Clotting in placental vessels
• Fetal growth restriction
• Miscarriage or stillbirth

Early detection allows for life-saving interventions like low-dose aspirin and heparin—proven to improve live birth rates.

Symptoms That Indicate This Test

Consider the Recurrent Abortion Genetic Profile if you have:

• Two or more unexplained miscarriages (before 20 weeks)
• Stillbirth or neonatal death with no clear cause
• Severe preeclampsia before 34 weeks
• Placental abruption or infarction on pathology
• Deep Vein Thrombosis (DVT) or Pulmonary Embolism (PE) in personal or family history
• Unexplained IVF implantation failure
• Family history of Factor V Leiden or early stroke

Even without symptoms, genetic clotting disorders can silently endanger pregnancy—this test detects them early.

Natural Production: How Clotting Proteins Protect Pregnancy

Your body naturally produces anticoagulant proteins to prevent excessive clotting:

• Protein C & S – work together to inactivate clotting factors Va and VIIIa
• Antithrombin III – inhibits thrombin and Factor Xa

But genetic mutations can disrupt this balance:

• Factor V Leiden – makes Factor V resistant to inactivation by Protein C → hypercoagulable state
• Protein C/S or Antithrombin III deficiency – reduces natural anticoagulant activity

During pregnancy, clotting tendency naturally increases to prevent bleeding at delivery. But in women with thrombophilia, this can lead to placental microthrombi, cutting off oxygen and nutrients to the fetus.

This test identifies inherited risks—so they can be managed.

What Happens If Untreated? Risks of Ignoring Thrombophilia

Ignoring clotting disorders in pregnancy can lead to:

⚠️ Recurrent Miscarriage – especially in 2nd trimester
⚠️ Stillbirth or Intrauterine Fetal Demise (IUFD)
⚠️ Placental Abruption – life-threatening for mother and baby
⚠️ Preeclampsia & Eclampsia – due to placental ischemia
⚠️ Maternal DVT or Pulmonary Embolism – high risk postpartum

The good news? With treatment, live birth rates in women with thrombophilia increase from ~40% to over 80%.

Early testing = higher chance of a healthy baby.

How to Prepare for the Test

To ensure accurate results:

✅ No fasting required
✅ Avoid heparin or warfarin (if possible)—these affect Protein C/S and Antithrombin
✅ Inform your doctor if you’re:

• On oral contraceptives or hormone therapy (can lower Protein S)
• Pregnant (some levels change during pregnancy)
• Recently had a clot or infection
  ✅ No strenuous exercise before testing

A blood sample is collected:

• Plasma (light blue top) for functional assays
• Whole blood (EDTA) for DNA testing (Factor V Leiden)

Our trained phlebotomists ensure a comfortable, discreet experience—available at clinics or via home collection.

Test Overview: Advanced Functional & Molecular Methodology

• Protein C & S: Functional Assay & ELISA
• Antithrombin III: Chromogenic Assay
• Factor V Leiden: PCR (Polymerase Chain Reaction)
• APCR: Coagulation Assay
  | Turnaround Time (TAT) | 7 Days (In-House), 14 Days (if outsourced) | | Category | Genetic & Coagulation Testing for Reproductive Health | | Purpose | Diagnose inherited thrombophilia in recurrent pregnancy loss | | Testing Location | Lab Tests Dubai – Accredited Labs & Home Collection Across UAE |

Interpretation:

• Factor V Leiden Mutation – Present/Absent (DNA-based)
• APCR – Positive if resistance detected
• Protein C/S, Antithrombin III – Reported as % activity (deficiency if <20–30%)

Results include clinical notes for your fertility specialist or OB-GYN.

FAQs About the Recurrent Abortion Genetic Profile

Q: Can I test while pregnant?
A: Yes—but Protein S levels drop in pregnancy, so results may need postpartum confirmation.

Q: Is this test only for women?
A: No. Men can carry Factor V Leiden and pass it to children—testing supports family planning.

Q: Can lifestyle changes help?
A: No. These are genetic conditions—but treatment (heparin, aspirin) is highly effective.

Q: Can I book without a doctor’s referral?
A: Yes! Lab Tests Dubai allows direct online booking—ideal for proactive fertility planning.

Q: How will I get results?
A: A secure digital report is emailed within 7 business days, including all markers and clinical notes.

Q: Is this test covered by insurance?
A: Yes. Recurrent miscarriage workups are medically necessary—covered by most UAE insurers.

If you’ve experienced heartbreak from repeated miscarriages, the Recurrent Abortion Genetic Profilegives you the answers you need in just 7 days.