Hereditary Cancer Gene Panel – 57 ACMG Genes for Genetic Risk Screening

The Hereditary Cancer Gene Panel – 57 ACMG Genes from Lab Tests Dubai is a comprehensive, next-generation sequencing (NGS) test that analyzes 57 clinically actionable genes recommended by the American College of Medical Genetics and Genomics (ACMG) for inherited cancer risk.

This advanced panel detects pathogenic mutations linked to hereditary cancer syndromes, including:

• ✅ BRCA1 / BRCA2 – Hereditary Breast & Ovarian Cancer (HBOC)
• ✅ TP53 – Li-Fraumeni Syndrome (multiple early cancers)
• ✅ MLH1, MSH2, MSH6, PMS2, EPCAM – Lynch Syndrome (colorectal, endometrial, ovarian)
• ✅ PALB2, CHEK2, ATM – High-risk breast and pancreatic cancer
• ✅ APC – Familial Adenomatous Polyposis (FAP)
• ✅ PTEN – Cowden Syndrome (breast, thyroid, endometrial)
• ✅ CDH1 – Hereditary Diffuse Gastric Cancer
• ✅ STK11 – Peutz-Jeghers Syndrome

This test is essential for:

• Identifying inherited mutations that increase lifetime cancer risk
• Guiding enhanced screening (e.g., breast MRI, colonoscopy)
• Enabling risk-reducing interventions (e.g., prophylactic surgery)
• Informing treatment decisions (e.g., PARP inhibitors for BRCA+ cancers)
• Protecting family members through cascade testing

Using advanced NGS technology, this saliva or blood-based test delivers highly accurate resultswithin 14–21 days—so you can act before cancer develops.

Available with private home collection, Lab Tests Dubai ensures confidential, stress-free, and science-driven care helping you take control of your genetic destiny.

Why You Need This Test

If you’ve had cancer before 50, or have relatives with multiple cancers, this test could reveal an inherited mutation so you can prevent cancer, not just treat it.

You need the 57-Gene Hereditary Cancer Panel if:

• You were diagnosed with breast, ovarian, or colorectal cancer under age 50
• You have two or more family members with related cancers
• A relative tested positive for BRCA, Lynch, or another cancer gene mutation
• You’ve had multiple primary cancers
• You’re considering preventive mastectomy or oophorectomy
• You want to protect your children’s future health

This test helps:

• Confirm or rule out hereditary cancer syndromes
• Personalize your screening schedule
• Guide life-saving surgeries or medications
• Empower relatives to get tested
• Optimize cancer treatment if diagnosed

Knowledge prevention, power, and peace of mind.

Who Should Consider This Test?

The Hereditary Cancer Gene Panel is recommended for:

• Individuals with Strong Family History of Cancer

Especially breast, ovarian, colorectal, pancreatic, prostate, or uterine cancers.

• Early-Onset Cancer Survivors

Diagnosed before age 50.

• People with Multiple Primary Cancers

e.g., breast and ovarian; colorectal and endometrial.

• Relatives of Known Mutation Carriers

For cascade testing and early protection.

• Women Planning Pregnancy or IVF

To assess inherited risks and reproductive options.

• Health-Conscious Individuals Over 30

Seeking proactive, long-term wellness.

This test aligns with NCCN, ACMG, and ESMO guidelines and is increasingly considered standard of care in high-risk populations.

How Hereditary Cancers Work: The Role of Genes

Most cancers are sporadic, but 5–10% are hereditary caused by inherited mutations passed down from parent to child.

These mutations affect genes that:

• Control cell growth (oncogenes)
• Repair DNA damage (tumor suppressors)
• Regulate apoptosis (cell death)

When broken, cells grow uncontrollably → cancer.

Common syndromes detected:

A single test can change the course of a family’s health history.

What Happens If You Skip Genetic Testing?

Ignoring hereditary cancer risk can lead to:

• Late-stage diagnosis due to lack of early screening
• Higher mortality from preventable cancers
• Missed prevention opportunities like risk-reducing surgery
• Unaware relatives who may also carry the mutation
• Ineffective treatments without knowledge of targetable mutations

The good news? Most hereditary cancers are preventable with:

• Enhanced surveillance (annual MRI, colonoscopy)
• Risk-reducing surgeries (oophorectomy, mastectomy)
• Medications (tamoxifen, aspirin)
• Lifestyle changes (diet, exercise, smoking cessation)

Early testing longer, healthier life for you and your family.

How to Prepare for the Test

To ensure accurate results:

• No fasting required

• Continue regular medications

• Inform your doctor of:

• Personal cancer history

• Family tree with cancer diagnoses

• Prior genetic testing results

A simple sample is collected at home or in clinic then sent to our partner lab for analysis.

Test Overview: 57-Gene Hereditary Cancer Panel

Report Includes

• Variant classification (Pathogenic, VUS, Negative)
• Associated cancer risks and lifetime probabilities
• NCCN guideline-based management recommendations
• Options for family testing (cascade screening)

Note: Not a diagnostic test for active cancer used for risk assessment only.

Benefits of the 57-Gene Hereditary Cancer Panel

• Detects Hidden Inherited Risk

Even without knowing full family history.

• Guides Life-Saving Prevention

MRI, colonoscopy, surgery options.

• Empowers Family Awareness

Protect siblings, children, and cousins.

• Supports Precision Treatment

e.g., PARP inhibitors for BRCA+ cancers

• Peace of Mind

Know your risk—or rule it out.

If you’re worried about your family’s cancer history, the Hereditary Cancer Gene Panel – 57 ACMG Genes gives you the answers you need in 14–21 days.