Diaminated Gliadin peptide IgA Test

Description

Deamidated Gliadin Peptide (DGP) IgA Test – Accurate Detection of Gluten-Induced Autoimmunity

The Deamidated Gliadin Peptide (DGP) IgA Test from Lab Tests Dubai is a highly specific blood test that detects IgA antibodies against deamidated gliadin peptides—a modified form of gluten that triggers the immune response in celiac disease.

Unlike traditional gliadin antibody tests, DGP IgA uses synthetic deamidated peptides to improve sensitivity and specificity, making it a critical tool in the modern diagnosis of celiac disease—especially in:

• Children under 2 years (where tTG IgA may be less sensitive)
• Patients with selective IgA deficiency
• Individuals with mild or atypical symptoms
• Monitoring gluten-free diet compliance

Using high-sensitivity chemiluminescence technology, this serum-based test delivers accurate results within 7 days, helping gastroenterologists and pediatricians diagnose celiac disease earlier and more reliably.

Available with home blood collection, Lab Tests Dubai ensures fast, accurate, and stress-free testing—so you can protect your gut health with confidence.

Why You Need This Test

If you or your child suffers from chronic bloating, anemia, or unexplained fatigue after eating gluten, this test could reveal celiac disease—the autoimmune condition behind your symptoms.

You need the DGP IgA Test if:

• You have diarrhea, bloating, or abdominal pain after wheat
• You suffer from iron-deficiency anemia or low bone density
• Your child shows failure to thrive, delayed growth, or irritability
• You’ve tested negative for tTG IgA but still suspect celiac
• You have selective IgA deficiency (requires DGP IgG as well)
• You’re being evaluated for dermatitis herpetiformis or autoimmune thyroiditis

This test helps:

• Improve celiac detection in young children
• Support diagnosis when tTG IgA is borderline
• Monitor dietary adherence
• Prevent long-term complications like osteoporosis and cancer

Early detection = healing of the gut and restored nutrient absorption.

Symptoms That Indicate This Test

Consider the DGP IgA Test if you or your child experience:

✅ Classic Gastrointestinal Symptoms:

• Chronic diarrhea or constipation
• Abdominal pain, bloating, gas
• Nausea or vomiting after gluten

✅ Non-GI & Systemic Symptoms:

• Iron-deficiency anemia (not due to blood loss)
• Osteoporosis or frequent fractures
• Fatigue, brain fog, depression
• Joint pain or tingling in hands/feet (neuropathy)

✅ For Children:

• Failure to thrive or delayed puberty
• Dental enamel defects
• Irritability or poor concentration

✅ Dermatological:

• Dermatitis herpetiformis – itchy, blistering rash (elbows, knees)

These signs may point to gluten-induced autoimmunity—and this test helps start the diagnostic journey.

Natural Production: How DGP Antibodies Signal Celiac Disease

Gliadin is a gluten protein in wheat that, when digested, is modified by the enzyme tissue transglutaminase (tTG) into deamidated gliadin peptides (DGP).

In genetically susceptible individuals (HLA-DQ2/DQ8), the immune system sees DGP as foreign and produces:

• IgA anti-DGP antibodies (in the gut and blood)
• These antibodies contribute to intestinal inflammation and villous atrophy

Why DGP IgA Matters:

• More sensitive than older anti-gliadin tests
• Highly specific for celiac disease
• Particularly useful in young children, where tTG IgA may be negative
• Often used alongside tTG IgA and total IgA for full screening

This test detects IgA anti-DGP antibodies—a powerful marker of active celiac disease.

What Happens If Untreated? Risks of Ignoring Celiac Disease

Ignoring celiac disease can lead to:

⚠️ Chronic Malnutrition – deficiencies in iron, calcium, B12, folate
⚠️ Osteoporosis & Fractures – from poor calcium absorption
⚠️ Infertility & Miscarriage – due to malabsorption and inflammation
⚠️ Neurological Issues – ataxia, neuropathy, migraines
⚠️ Increased Cancer Risk – enteropathy-associated T-cell lymphoma (EATL)
⚠️ Other Autoimmune Diseases – type 1 diabetes, thyroiditis

The good news? Celiac disease is 100% treatable with a strict, lifelong gluten-free diet—no medication required.

Early testing = full intestinal healing and normal life expectancy.

How to Prepare for the Test

To ensure accurate results:

✅ Continue eating gluten – at least 1-2 servings per day for 6–8 weeks before testing
❌ Do NOT go gluten-free before testing – can cause false-negative results
✅ No fasting required
✅ Inform your doctor of:

• Recent infections or steroid use
• History of IgA deficiency
• Current GI symptoms

A serum blood sample is collected via standard draw—available at our labs or via home collection.

Test Overview: High-Sensitivity Chemiluminescence Method

Interpretation:

• <10 U/mL → Negative
• 10–15 U/mL → Equivocal
• >15 U/mL → Positive (high likelihood of celiac)

Note: Often paired with tTG IgA, Total IgA, and EMA for full celiac panel.

Benefits of the DGP IgA Blood Test

🔹 Early Celiac Diagnosis
Detect disease before irreversible damage occurs.

🔹 Superior in Children
More sensitive than tTG IgA in young kids.

🔹 Supports IgA-Deficient Patients
Used with DGP IgG when Total IgA is low.

🔹 Monitor Gluten-Free Diet
Antibody levels drop with dietary adherence.

🔹 Improve Long-Term Health
Prevent anemia, osteoporosis, and cancer.

If you’re tired of bloating, fatigue, or unexplained anemia, the Deamidated Gliadin Peptide IgA Test gives you the answers you need in just 7 days.