BRCA 1&2 Somatic Test Panel – Detect Tumor Mutations for Breast & Ovarian Cancer

BRCA 1&2 Somatic Test – Detect Tumor Mutations for Breast & Ovarian Cancer

The BRCA 1&2 Somatic Gene Panel identifies tumor-specific mutations in cancer tissue. Results in 10 days. Essential for targeted therapy. Book with Lab Tests Dubai.

Why You Need This Test

The BRCA 1&2 Somatic Gene Panel is an advanced molecular diagnostic test that detects acquired (somatic) mutations in the BRCA1 and BRCA2 genes within tumor tissue—not inherited from family. These mutations are commonly found in:

• Breast cancer (especially triple-negative)
• Ovarian, fallopian tube, and peritoneal cancers
• Prostate and pancreatic cancers (in some cases)

Unlike germline testing (which assesses inherited risk), this somatic test analyzes the tumor itself to:

• Guide targeted cancer therapies like PARP inhibitors (e.g., Olaparib, Niraparib)
• Predict treatment response and prognosis
• Support personalized oncology treatment plans
• Identify patients eligible for clinical trials

This test is crucial for patients already diagnosed with cancer and undergoing treatment planning.

Symptoms That Indicate This Test

This test is not for screening but is recommended for individuals already diagnosed with:

• Breast cancer (especially if diagnosed under 50 or with triple-negative subtype)
• Ovarian, fallopian tube, or primary peritoneal cancer
• Metastatic prostate or pancreatic cancer
• A strong family history of BRCA-related cancers
• Tumors showing genomic instability on other tests

It’s typically ordered by an oncologist after a biopsy or surgery.

Natural Production & Genetic Basis

BRCA1 and BRCA2 are tumor suppressor genes that help repair damaged DNA and maintain genomic stability.

• Somatic mutations occur only in tumor cells during a person’s life due to environmental factors, aging, or random errors in cell division.
• These are not inherited and cannot be passed to children.
• When these genes are mutated in cancer cells, DNA repair fails, leading to uncontrolled cell growth.

The BRCA 1&2 Somatic Gene Panel uses Next-Generation Sequencing (NGS) to detect these mutations in tumor tissue, helping oncologists choose the most effective treatments.

What Happens If Untreated or Undiagnosed

Ignoring BRCA somatic status can lead to:

• Suboptimal treatment with chemotherapy instead of targeted therapy
• Missed opportunity for PARP inhibitors, which improve progression-free survival
• Poorer prognosis in aggressive cancers
• Increased risk of recurrence

Knowing your tumor’s BRCA status empowers your care team to use precision medicine—maximizing effectiveness and minimizing unnecessary side effects.

How to Prepare for the Test

This test requires tumor tissue, not blood:

• Formalin-Fixed Paraffin-Embedded (FFPE) tissue block or slides from a prior biopsy or surgery
• Fresh tumor tissue (in specific cases)
• Clinical information about the cancer type and stage

No fasting or special preparation is needed from the patient—your oncologist or pathologist will coordinate sample submission.

Test Overview

Don’t miss the chance for targeted cancer treatment. The BRCA 1&2 Somatic Gene Panel provides critical insights into your tumor’s genetics—helping your oncologist choose the most effective, personalized therapy.

👉 Talk to your oncologist or contact Lab Tests Dubai to see if this test is right for you.

Your cancer journey deserves precision. Test smart. Treat better.