Y Chromosome Microdeletion Test for Men – Accurate Male Infertility Screening

Description

Y Chromosome Microdeletion (Only Males) Blood Test – Advanced Genetic Screening for Male Infertility

The Y Chromosome Microdeletion Test from Lab Tests Dubai is a specialized genetic blood testdesigned exclusively for men struggling with infertility due to low or absent sperm production affecting up to 10% of infertile men.

This advanced diagnostic test identifies microscopic deletions in the Y chromosome, specifically in the AZF (Azoospermia Factor) regions:

• ✅ AZFa
• ✅ AZFb
• ✅ AZFc

These regions contain genes essential for normal sperm development (spermatogenesis). Deletions here can cause:

• Azoospermia – No sperm in semen
• Severe Oligospermia – Extremely low sperm count

This test is essential for:

• Diagnosing genetic causes of male infertility
• Guiding decisions about IVF, ICSI, or surgical sperm retrieval (TESE)
• Determining if biological fatherhood is possible
• Preventing transmission of deletions to sons via ART
• Evaluating men before fertility preservation (e.g., pre-chemotherapy)

Using PCR-based molecular analysis, this blood-based test delivers highly accurate results within just 5 days so couples can move forward with confidence in their fertility journey.

Available with private home blood collection, Lab Tests Dubai ensures accuracy, discretion, and emotional support because male infertility is more common than you think.

Why You Need This Test

If you or your partner have been trying to conceive without success and a semen analysis shows very low or zero sperm count this test could reveal a genetic reason behind the issue.

You need the Y Chromosome Microdeletion Test if:

• Your semen analysis shows azoospermia or severe oligospermia
• You’re preparing for IVF/ICSI treatment
• You’re considering testicular sperm extraction (TESE or microTESE)
• There’s no clear cause of infertility after basic testing
• You want to understand whether biological fatherhood is possible
• You’re concerned about passing infertility to future sons

This test helps:

• Confirm or rule out a genetic cause of infertility
• Guide next steps in assisted reproduction
• Avoid unnecessary procedures if sperm retrieval is unlikely
• Inform family planning and genetic counseling
• Reduce emotional uncertainty during fertility treatment

Symptoms That Indicate This Test

Consider the Y Chromosome Microdeletion Test if:

• Semen analysis shows zero sperm (azoospermia) or <1 million/mL (severe oligospermia)
• Hormone tests are normal but sperm production is impaired
• You’ve had failed IVF cycles due to poor sperm quality
• You’re exploring surgical sperm retrieval options
• You have a family history of male infertility

Note: Most men with Y microdeletions have no other symptoms normal appearance, libido, and hormone levels. The only sign is abnormal semen parameters.

Natural Production: How the Y Chromosome Controls Sperm Production

The Y chromosome carries critical genes for male sexual development and sperm production, especially in the AZF region:

• AZFa: Genes like USP9Y, DDX3Y – crucial for early spermatogenesis
• AZFb: Genes like RBMY – involved in sperm cell maturation
• AZFc: DAZ gene family – most commonly deleted; affects sperm count

When parts of these regions are missing (microdeleted):

• Spermatogenesis is disrupted
• Sperm may be absent or severely reduced
• The condition is not inherited from father (arises spontaneously)
• But it will be passed to all male offspring conceived via ICSI

This test identifies which region is affected helping predict:

• Whether sperm might be found in the testicles
• Likelihood of successful TESE/ICSI
• Risk to future sons

What Happens If Untreated or Undiagnosed?

Ignoring a Y chromosome microdeletion can lead to:

⚠️ Repeated failed fertility treatments without understanding why
⚠️ Unnecessary surgeries (e.g., TESE when no sperm exists)
⚠️ Emotional strain on relationships and self-esteem
⚠️ Passing infertility to sons through ICSI without disclosure
⚠️ Delayed adoption or donor options due to unresolved diagnosis

The good news? Understanding the cause brings peace and direction.
With proper diagnosis:

• Couples can choose realistic paths (donor sperm, adoption, TESE)
• Men with AZFc deletions may still have retrievable sperm
• Genetic counseling prepares families for future implications

How to Prepare for the Test

To ensure accurate results:

✅ No fasting required
✅ Continue regular medications (inform doctor if on hormones)
✅ Provide details of:

• Recent semen analysis results
• History of testicular surgery or infections
• Use of steroids or anabolic supplements

A simple blood draw (EDTA tube) is collected available at our labs or via home collection.

Test Overview

Benefits of the Y Chromosome Microdeletion Test

🔹 Identifies Genetic Cause of Infertility
Ends the “why” behind low/no sperm.

🔹 Guides Fertility Treatment Decisions
Helps decide between TESE, ICSI, or donor options.

🔹 Prevents Unnecessary Procedures
Avoid surgery if sperm is genetically absent.

🔹 Supports Ethical Family Planning
Informs risk to male children via ICSI.

🔹 Provides Emotional Closure
Replaces uncertainty with answers.

If you’re facing low or zero sperm count, the Y Chromosome Microdeletion Test gives you the answers you need in 5 days.