HIGH RESOLUTION-HLA A B C DR DQ DP TYPING

Description

High-Resolution HLA A, B, C, DR, DQ, DP Typing – Precision Immunogenetic Analysis

The High-Resolution HLA (Human Leukocyte Antigen) A, B, C, DR, DQ, DP Typing test from Lab Tests Dubai is a gold-standard, next-generation sequencing (NGS)-based assay that identifies your exact HLA alleles at the highest possible resolution critical for successful organ transplantation, hematopoietic stem cell transplants (HSCT), and managing immune-related conditions.

HLA proteins are markers on cells that help the immune system distinguish “self” from “non-self.” When mismatched during transplantation, they can trigger:

• ❌ Graft rejection
• ❌ Graft-versus-host disease (GVHD)
• ❌ Poor graft survival

This comprehensive test analyzes:

• ✅ Class I Genes: HLA-A, HLA-B, HLA-C – Critical for solid organ and stem cell matching
• ✅ Class II Genes: HLA-DR, HLA-DQ, HLA-DP – Key in immune response and GVHD risk

Using NGS technology, this test delivers allele-level precision (e.g., HLA-B*15:02) far superior to low- or intermediate-resolution methods ensuring the best possible donor-recipient match.

With results in just 10 business days, Lab Tests Dubai empowers transplant teams, families, and patients to find life-saving matches faster and reduce post-transplant complications.

Available through partner transplant centers, this service ensures accuracy, reliability, and clinical actionability—because when it comes to transplants, every digit in the HLA code matters.

Why You Need This Test

If you or a loved one is preparing for a bone marrow, kidney, liver, or heart transplant, this test could be the difference between success and rejection.

You need High-Resolution HLA Typing if:

• You’re being evaluated for hematopoietic stem cell transplantation (HSCT)
• You’re a patient or donor in a family or unrelated donor search
• You have a relative with leukemia, thalassemia, or sickle cell disease
• You’re undergoing solid organ transplant workup (kidney, liver, heart)
• You suffer from recurrent miscarriages or autoimmune disorders linked to HLA
• You want to join a global donor registry (e.g., DKMS, Delete Blood Cancer)

This test helps:

• Identify perfect or near-perfect HLA matches
• Minimize risk of graft failure and GVHD
• Guide use of immunosuppressive therapy
• Support haploidentical transplant planning
• Inform reproductive risks in certain HLA-linked conditions

Who Should Take This Test?

The High-Resolution HLA Typing Test is essential for:

✅ Patients Awaiting Stem Cell or Bone Marrow Transplant
For blood cancers (leukemia, lymphoma) or genetic blood disorders.

✅ Potential Donors (Family Members or Volunteers)
To determine match status with a recipient.

✅ Organ Transplant Candidates
Kidney, liver, heart, lung recipients needing donor compatibility.

✅ Couples with Recurrent Pregnancy Loss
Linked to HLA-G or partner similarity in HLA profiles.

✅ Individuals with Autoimmune Diseases
e.g., Ankylosing spondylitis (HLA-B27), Narcolepsy (DQB106:02), T1D (DQB1*03:02)

✅ Researchers & Registries
Building databases for global donor matching.

How HLA Typing Works: The Science of Immune Compatibility

Your HLA genes are the most polymorphic in the human genome over 35,000 known alleles making matching extremely complex.

During transplantation:

• If donor and recipient HLA types don’t match, the immune system sees the new tissue as foreign
• T-cells attack the graft (rejection) or donor immune cells attack the host (GVHD)

High-resolution typing uses NGS or Sanger sequencing to identify alleles down to four-digit specificity (e.g., A*02:01)critical because:

• Even a single allele mismatch increases GVHD risk
• HLA-C and DP mismatches impact engraftment
• Certain alleles predict drug hypersensitivity (e.g., HLA-B*57:01 → abacavir allergy)

What Happens If You Skip High-Resolution HLA Typing?

Without precise HLA matching, patients may face:

⚠️ Higher rates of graft rejection
⚠️ Severe graft-versus-host disease (GVHD)
⚠️ Delayed engraftment or transplant failure
⚠️ Increased mortality post-transplant
⚠️ Unnecessary exclusion of partially matched donors

The good news? Perfect or well-matched transplants dramatically improve outcomes:

• 80–90% survival with matched sibling donors
• Reduced need for intense immunosuppression
• Faster recovery and lower infection risk

Testing better match, better survival.

How to Prepare for the Test

To ensure accurate results:

✅ Sample Type: Whole blood (EDTA tube) or extracted DNA
✅ No fasting required
✅ Provide details of:

• Clinical diagnosis (e.g., leukemia, renal failure)
• Relationship to recipient/donor
• Prior transplants or treatments

Test Overview

Benefits of High-Resolution HLA Typing

🔹 Maximizes Transplant Success
Reduces rejection and GVHD.

🔹 Identifies Best Donor Match
Even among family members.

🔹 Supports Haploidentical Transplants
With post-transplant cyclophosphamide.

🔹 Guides Personalized Immunosuppression
Based on mismatch burden.

🔹 Empowers Family Planning & Registry Enrollment
Protect future generations.

If you or a loved one is facing a life-saving transplant, the High-Resolution HLA A, B, C, DR, DQ, DP Typing Test gives you the precision you need in 10 days.