Extended ANA profile Test 44 Parameters

Description

Extended ANA Profile Test – 44 Parameters: Advanced Autoantibody Screening for Complex Autoimmune Diseases

The Extended ANA Profile Test – 44 Parameters from Lab Tests Dubai is a cutting-edge diagnostic panel that uses Micro Array Blot (MAB) technology to detect 44 specific autoantibodies associated with systemic autoimmune and connective tissue diseases.

This comprehensive test goes far beyond basic ANA screening, identifying rare and clinically significant autoantibodiesthat help diagnose and differentiate complex conditions such as:

• Systemic Lupus Erythematosus (SLE)
• Polymyositis & Dermatomyositis
• Clinically Amyopathic Dermatomyositis (CADM)
• Scleroderma (Systemic Sclerosis)
• Mixed Connective Tissue Disease (MCTD)
• Inflammatory Myopathies with Interstitial Lung Disease (ILD)

With a 3-day turnaround time, this test empowers rheumatologists and immunologists to make precise, early diagnoses—critical for preventing organ damage and guiding targeted therapy.

Available with home blood collection, Lab Tests Dubai brings world-class autoimmune profiling to your doorstep—ideal for patients with chronic fatigue, muscle weakness, or unexplained rashes.

Why You Need This Test

If you or your patient has complex, overlapping symptoms of autoimmune disease, a basic ANA test isn’t enough.

You need the Extended ANA Profile if:

• You have a positive ANA but unclear diagnosis
• You suffer from muscle weakness, skin rashes, or joint pain without clear cause
• You’re being evaluated for interstitial lung disease (ILD)
• You have Raynaud’s phenomenon, skin tightening, or calcinosis
• You’re suspected of anti-synthetase syndrome, dermatomyositis, or overlap syndromes
• You’re on immunosuppressive therapy and need baseline autoantibody profiling

This 44-parameter panel detects disease-specific antibodies that:

• Predict organ involvement (e.g., lung, skin, heart)
• Guide treatment choices (e.g., IVIG, rituximab)
• Help assess prognosis (e.g., anti-MDA5 = high ILD risk)

This is precision medicine for autoimmune disorders.

Symptoms That Indicate This Test

Consider the Extended ANA Profile if you experience:

✅ For Myositis & Dermatomyositis:

• Proximal muscle weakness (difficulty rising from chair)
• Gottron’s papules, heliotrope rash
• Mechanic’s hands
• Interstitial lung disease (shortness of breath)

✅ For Scleroderma:

• Skin thickening or tightening
• Raynaud’s phenomenon
• Telangiectasia, calcinosis
• Difficulty swallowing (esophageal dysmotility)

✅ For Lupus & Overlap Syndromes:

• Malar (butterfly) rash
• Photosensitivity
• Oral ulcers
• Arthritis, serositis

✅ Other Indicators:

• Chronic dry eyes/mouth (Sjögren’s)
• Unexplained fevers or weight loss
• Elevated CK or inflammatory markers

These symptoms may indicate rare or overlapping autoimmune conditions—and this test provides definitive answers.

Natural Production: Why Autoantibodies Appear in Autoimmune Disease

The immune system normally produces antibodies to fight infections. But in autoimmune diseases, it mistakenly attacks self-antigens in the nucleus, cytoplasm, and muscle cells.

Key triggers:

• Genetic predisposition (e.g., HLA-DR alleles)
• Environmental factors (UV light, infections, drugs)
• Molecular mimicry (viral proteins resemble self-antigens)
• Immune dysregulation

The Extended ANA Profile detects these misguided autoantibodies, which serve as biomarkers for specific diseases:

• Anti-Jo-1, PL-7, PL-12 → Anti-synthetase syndrome
• Anti-MDA5, NXP2 → Dermatomyositis with ILD
• Anti-TIF1γ → Cancer-associated dermatomyositis
• Anti-HMGCR → Statin-associated myopathy
• Anti-SRP, Mi-2 → Necrotizing or classic dermatomyositis
• Anti-POLR3A, CENP B → Scleroderma subtypes

This test helps stratify risk, predict complications, and personalize treatment.

What Happens If Untreated? Risks of Delayed or Missed Diagnosis

Ignoring complex autoimmune symptoms can lead to:

⚠️ Progressive Organ Damage – lung fibrosis, heart failure
⚠️ Severe Muscle Atrophy – from untreated myositis
⚠️ Renal Crisis – in scleroderma
⚠️ Increased Cancer Risk – with anti-TIF1γ
⚠️ Life-Threatening ILD – especially in anti-MDA5+ patients

Early detection via the Extended ANA Profile allows for:

• Aggressive immunosuppression when needed
• Cancer screening in high-risk cases
• Lung monitoring with HRCT
• Timely intervention before irreversible damage

This test doesn’t just diagnose—it saves lives.

How to Prepare for the Test

Preparing for the Extended ANA Profile is simple:

✅ No fasting required
✅ Continue your regular medications—but inform your doctor
✅ Avoid intense exercise or illness 24 hours before (can affect CK and immune markers)
✅ Stay hydrated and relaxed

A serum blood sample is collected via standard draw—available at our labs or via home collection.

Test Overview: Advanced Micro Array Blot (MAB) Methodology

Feature	Details
Test Name	Extended ANA Profile – 44 Parameters
Sample Type	Serum (Blood)
Methodology	Micro Array Blot (MAB) / Line Immunoassay
Turnaround Time (TAT)	3 Days
Category	Autoimmune Disease Testing / Rheumatology Diagnostics
Purpose	Diagnose complex autoimmune & connective tissue diseases
Testing Location	Lab Tests Dubai – Accredited Labs Across UAE

Micro Array Blot (also called multiplex line immunoassay) offers:

• High specificity – detects individual autoantibodies
• Simultaneous 44-marker analysis
• Low false-positive rate
• Semi-quantitative results (weak, moderate, strong)

Key Antibodies Detected:

• Myositis Panel: Jo-1, PL-7, PL-12, EJ, OJ, KS, HMGCR, SRP, Mi-2, MDA5, NXP2, TIF1γ
• Scleroderma Panel: Scl-70, CENP A/B, POLR3A, Th/To, NOR90, Fibrillarin
• Lupus & Overlap: dsDNA, Sm, RNP, Ro52, Ro60, La, PCNA, Ku, P0
• Unique Markers: DFS70 (non-autoimmune), PDGFR-β (scleroderma), SAE-1/2 (overlap)

Results include positive/negative status, intensity, and clinical correlation notes.

FAQs About the Extended ANA Profile Test

Q: How is this different from a basic ANA test?
A: Basic ANA (IIF) is a screening test. This is a reflex panel that identifies 44 specific antibodies for precise diagnosis.

Q: Can this test detect cancer-associated myositis?
A: Yes. Anti-TIF1γ is strongly linked to underlying malignancy—triggers cancer screening.

Q: Can medications affect results?
A: Yes. Statins can induce anti-HMGCR; TNF inhibitors may trigger autoantibodies.

Q: Can I book without a doctor’s referral?
A: Yes! Lab Tests Dubai allows direct online booking—ideal for proactive screening (with clinical context).

Q: How will I get results?
A: A secure digital report is emailed within 3 business days, including all 44 markers and clinical notes.

Q: Is this test covered by insurance?
A: Yes. Complex autoimmune panels are medically necessary—covered by most UAE insurers.

If you’re struggling with unexplained pain, fatigue, or rashes, the Extended ANA Profile – 44 Parametersgives you the most comprehensive autoimmune screening in Dubai.