MTRR A66G Genetic Test – Personalized Health & Methylation Analysis

Description

MTRR A66G Genetic Test – Precision Screening for Methylation & Vitamin B12 Recycling

The MTRR A66G Genetic Test from Lab Tests Dubai is a specialized DNA analysis that detects a common but impactful single nucleotide polymorphism (SNP) in the MTRR gene a key player in your body’s methylation cycle and vitamin B12 metabolism.

This SNP, known as A66G (rs1801394), affects how efficiently your body:

• ✅ Recycles vitamin B12 (cobalamin)
• ✅ Converts homocysteine to methionine
• ✅ Supports DNA synthesis, nerve function, and detoxification

When impaired, this can lead to:

• Elevated homocysteine levels (linked to heart disease, stroke)
• Reduced energy production
• Impaired fertility and pregnancy outcomes
• Increased risk of neurological issues (brain fog, depression, neuropathy)

This test is essential for:

• Individuals with high homocysteine despite normal B12 levels
• Those with chronic fatigue, mood disorders, or cognitive decline
• Women experiencing recurrent miscarriages or fertility challenges
• Patients with MTHFR mutations who need full methylation pathway insight
• People optimizing health through functional or integrative medicine

Using advanced NGS or PCR-based genotyping, this non-invasive saliva test delivers accurate results within 2–3 weeks so you can personalize supplementation and support your biochemistry at the genetic level.

Available with home sample collection, Lab Tests Dubai ensures privacy, precision, and proactive care empowering you to thrive, not just survive.

Why You Need This Test

If you’re struggling with low energy, brain fog, or unexplained fertility issues, this test could reveal a hidden genetic reason why B12 supplements aren’t working and what form of B12 your body actually needs.

You need the MTRR A66G Test if:

• You have elevated homocysteine on blood tests
• You’re vegetarian, vegan, or low-meat eater at risk of B12 deficiency
• You suffer from chronic fatigue, anxiety, or depression
• You’ve had recurrent miscarriages or infertility
• You already know you have an MTHFR mutation (C677T/A1298C)
• You take B12 but still feel tired or mentally foggy

This test helps:

• Identify impaired B12 recycling due to genetics
• Guide use of active B12 forms (methylcobalamin, adenosylcobalamin)
• Reduce homocysteine naturally with targeted nutrients
• Support fertility, pregnancy, and fetal development
• Optimize methylation for detox, mood, and energy

Knowledge  better B12 utilization, not more pills.

Symptoms That Indicate This Test

Consider the MTRR A66G Test if you experience:

✅ For Methylation & B12 Dysfunction:

• Chronic fatigue or low stamina
• Brain fog, poor memory, or difficulty concentrating
• Depression, anxiety, or mood swings
• Numbness or tingling in hands/feet (neuropathy)

✅ For Fertility & Pregnancy:

• Recurrent miscarriages
• Infertility or implantation failure
• History of neural tube defects (NTDs)

✅ For Cardiovascular Risk:

• High homocysteine levels (>10 µmol/L)
• Family history of heart attack or stroke at young age

These signs may point to methylation imbalance and this test helps start the right treatment.

Natural Production: How MTRR Supports Methylation

The methylation cycle is a vital biochemical process involved in:

• DNA repair
• Detoxification
• Neurotransmitter production (serotonin, dopamine)
• Immune function
• Fetal development

Two key enzymes are involved:

• MTR (Methionine Synthase) – Uses vitamin B12 to convert homocysteine → methionine
• MTRR (Methionine Synthase Reductase) – Recycles and reactivates MTR using B12

The A66G variant (GG genotype) reduces MTRR enzyme efficiency by up to 50%, leading to:

• Slower B12 recycling
• Functional B12 deficiency (even with normal serum levels)
• Homocysteine buildup
• Reduced methylation capacity

This creates a bottleneck especially when combined with MTHFR mutations.

What Happens If Untreated? Risks of Ignoring MTRR A66G

Ignoring impaired MTRR function can lead to:

⚠️ Elevated Homocysteine – increases risk of heart disease, stroke, dementia
⚠️ Neurological Decline – neuropathy, cognitive impairment, depression
⚠️ Fertility Issues – recurrent miscarriage, poor egg/sperm quality
⚠️ Pregnancy Complications – preeclampsia, preterm birth, NTDs
⚠️ Chronic Fatigue & Poor Recovery – due to low methylation

The good news? This is highly manageable with:

• Active B12 supplements (methyl- and adenosylcobalamin)
• Folate (as methylfolate) – especially if MTHFR+
• Betaine (TMG) – supports alternative homocysteine clearance
• Lifestyle support (sleep, stress reduction, toxin avoidance)

Early testing prevention of long-term damage.

How to Prepare for the Test

To ensure accurate results:

✅ No fasting required
✅ Avoid eating, drinking (except water), smoking, or chewing gum 30 minutes before sample collection
✅ Use the sterile saliva or buccal swab kit provided
✅ Follow the step-by-step instructions for sealing and mailing

A simple at-home sample is collected and shipped to our partner lab no blood, no clinic visit.

Test Overview: MTRR A66G Genotyping

Genotype Interpretation:

• AA (Wild Type) – Normal enzyme function
• AG (Heterozygous) – Moderate reduction in activity (~30%)
• GG (Homozygous) – Significant reduction (~50%) – higher need for active B12

Report Includes:

• Your genotype (AA, AG, GG)
• Clinical implications
• Personalized recommendations:
  • Best forms of B12 and folate
  • Diet & lifestyle tips
  • Supplement guidance (dose, timing)
  • When to retest homocysteine

Benefits of the MTRR A66G Test

🔹 Personalizes B12 Supplementation
Stop guessing—use the right form for your genes.

🔹 Reduces Homocysteine Naturally
Protect your heart and brain.

🔹 Supports Fertility & Pregnancy
Critical for fetal neural development.

🔹 Improves Energy & Mental Clarity
By fixing methylation at the root.

🔹 Complements MTHFR Testing
Complete picture of your methylation pathway.

If you’re tired of feeling tired, foggy, or stuck, the MTRR A66G Test gives you the answers you need in 2–3 weeks.