BRCA 1&2 MUTATION DETECTION (Germline) with MLPA

Description

BRCA 1&2 Mutation Detection with MLPA – Know Your Hereditary Cancer Risk

The BRCA1 & BRCA2 Deletion & Duplication Detection Test using MLPA (Multiplex Ligation-dependent Probe Amplification) is a comprehensive genetic test that identifies large-scale gene rearrangements, including deletions and duplications, in the BRCA1 and BRCA2 genes, which are linked to significantly increased risks of hereditary breast, ovarian, prostate, and pancreatic cancers.

While many tests only detect small mutations (via sequencing), this advanced MLPA method uncovers large genomic changes that standard tests miss, ensuring a complete evaluation of your genetic risk.

Offered at Lab Tests Dubai with strict quality controls and expert interpretation, this test is essential for individuals with a strong family history of cancer, those who’ve had early-onset disease, or anyone seeking clarity about their inherited cancer risk.

Knowledge is power. And when it comes to hereditary cancer, early awareness can save lives.

Why You Need This Test

You need the BRCA1 & BRCA2 MLPA Test if:

• You’ve been diagnosed with breast cancer before age 50
• You have triple-negative breast cancer (especially under 60)
• You or a family member has ovarian, fallopian tube, or primary peritoneal cancer
• Multiple relatives have had breast, ovarian, or prostate cancer
• A known BRCA mutation exists in your family
• You’re considering preventive measures like enhanced screening or prophylactic surgery
• You’re planning pregnancy and want to assess genetic risk to children

This test completes the picture after or alongside BRCA sequencing, detecting large exonic deletions/duplications responsible for up to 10–15% of hereditary BRCA mutations, especially common in certain ethnic groups.

It’s not just about you, it’s about protecting your family’s future.

This test is indicated by personal or family medical history, such as:

• Breast cancer diagnosis before age 50
• Ovarian cancer at any age
• Male breast cancer
• Bilateral breast cancer
• Ashkenazi Jewish ancestry with any breast/ovarian cancer
• Family cluster of breast, ovarian, or aggressive prostate cancer

If your story includes any of these, you may carry a BRCA gene rearrangement even if prior sequencing was negative.

Natural Production (Clarification: BRCA Genes & Function)

Your body naturally produces BRCA1 and BRCA2 proteins, which act as tumor suppressors, repairing damaged DNA and maintaining genomic stability.

When either gene carries a harmful mutation (like a deletion or duplication), the protein doesn’t work properly, increasing the risk of uncontrolled cell growth and cancer.

These mutations are inherited in an autosomal dominant pattern, meaning each child of a carrier has a 50% chance of inheriting the faulty gene.

The MLPA test detects missing or extra segments in the BRCA genes, revealing mutations that disrupt normal function and elevate lifetime cancer risk:

• Up to 72% risk of breast cancer (vs. 13% general population)
• Up to 44% risk of ovarian cancer (BRCA1)
• Increased risk of prostate, pancreatic, and melanoma cancers

Early detection enables lifesaving interventions.

What Happens If Untreated / Undiagnosed

Without testing:

• High-risk individuals remain unaware until cancer develops
• Cancers are often diagnosed at later stages due to lack of screening
• Family members unknowingly inherit the mutation
• Missed opportunities for risk-reducing surgeries or targeted therapies (e.g., PARP inhibitors)
• Psychological distress from uncertainty

With results, you can:

• Start annual MRI + mammogram screening earlier
• Consider prophylactic mastectomy or oophorectomy
• Inform relatives so they can get tested
• Access targeted treatments if cancer occurs

Genetic insight transforms fear into action.

How to Prepare for the Test

Preparation is simple:

• No fasting required
• Continue regular medications
• Avoid blood transfusions within 72 hours (can affect DNA results)

🔹 Sample Requirements:

• 4 mL whole blood (minimum 3 mL) in 1 Lavender-top (EDTA) tube
• Must be labeled with full name, DOB, and collection date

🔹 Mandatory Documentation:

• Completed Genomic Test Request Form (TRF)
• Signed Informed Consent Form
• Detailed clinical and family history (cancer types, ages at diagnosis)

Our team supports secure logistics and coordination. We offer home blood collection across Dubai & UAE

Test Overview

FAQs

Q: Is this test the same as BRCA sequencing?
A: No. Sequencing finds small mutations; MLPA finds large deletions/duplications. Both are needed for full analysis.

Q: Can men take this test?
A: Yes. Men with BRCA mutations have higher risks of male breast, prostate, and pancreatic cancer.

Q: Do I need a doctor’s referral?
A: Yes. Due to complexity, a prescription and detailed family history are mandatory.

Q: Will insurance cover it?
A: Many insurers cover BRCA testing for high-risk individuals. We provide documentation for claims.

Q: What if I test positive?
A: You’ll receive guidance on next steps — including enhanced screening, preventive options, and family testing.

Q: Should my children be tested?
A: Not routinely. Predictive testing is usually offered at age 25+ unless clinical need arises.

Q: Is my result confidential?
A: Absolutely. All genetic data is encrypted and shared only with authorized providers.

🧬 One test could change your family’s health legacy forever.
The BRCA1 & BRCA2 MLPA Test gives you complete insight into your hereditary cancer risk, so you can take control before cancer strikes. Book a test today with Lab Tests Dubai.